|
 |
|
|
Video Endoscopic Sequence 1 of 3.
Massive Upper Gastrointestinal Bleeding.
In this video clip, you can observe one of the worst bleeding of the gastrointestinal track.
It is more difficult to stop bleeding from the gastric varices than from the esophageal varices. The rate of hemostasis by endoscopic management is higher with the Histoacryl than that with the other sclerosing agents such as 5% ethanolamine oleate.
After introducing N-butyl-2 -cyanoacrylate (Histoacryl) to the management of bleeding gastric varices, the hemostasis rate improves to almost 100% However, the rebleeding rate is still high if any further additional treatment has not been performed until the gastric varices have been eradicated. There is still a controversy regarding the management for the gastric varices.
For more endoscopic details, download the video clips by clicking on the endoscopic images. Wait to be downloaded complete then Press Alt and Enter for full screen. All endoscopic images shown in this Atlas contain video clips. We recommend seeing the video clips in full screen mode. Medline.
|
|
|
 |
|
|
Video Endoscopic Sequence 2 of 3.
Bleeding from gastric varices is a life-threatening complication of portal hypertension. Fundal and isolated gastric varices are at high risk for variceal bleeding.
|
|
|
 |
|
|
Video Endoscopic Sequence 3 of 3.
Argon Plasma Coagulation was used as a emergency tool.
Gastric varices occur in about 20% of patients with portal hypertension and approxiamately 25% of gastric varices bleed during lifetime. Gastric variceal bleeding has a higher rate of recurrence than esophageal variceal bleeding, and is associated with decreased survival. The cumulative mortality of fundal varices reaches as high as 52% at the end of 1 year.
|
|
|
 |
|
|
Video Endoscopic Sequence 1 of 7.
This 66 year old female, presented with massive upper gastrointestinal bleeding. Endoscopy revealed spurting from a large varix in the gastric fundus.
Bleeding from gastric varices is a life-threatening event that presents a therapeutic challenge for clinicians.
|
|
|
 |
|
|
Video Endoscopic Sequence 2 of 7.
Active pulsatile bleeding from a gastric fundic, varix was seen at endoscopy.
Gastric Varices are much less common cause of variceal hemorrhage than esophageal ones; but are important to recognize as the source of bleeding because their management is different. When gastric varices are prominent and associated with minimal to absent esophageal varices, one must consider splecnic vein thrombosis as the etiology of the increased venous pressures. Angiography may verify this diagnosis. These patients are best treated with simple splecnectomy, which adequately decompresses their varices. Such patients have an excellent prognosis because of the lack of underlying liver disease. Splecnic vein thrombosis may occur as a complication of pancreatitis due to contiguous inflammation from the body and tail of the pancreas. Histoacryl (N-butyl-2-cyanocrylate) has been used in bleeding esophagogastric and ectopic varices.
Medline.
|
|
|
 |
|
|
Video Endoscopic Sequence 3 of 7.
Continuous flow of blood from the varix.
Gastric varices occur in about 20% of patients with portal hypertension and approximately 25% of gastric varices bleed during lifetime. Gastric variceal bleeding especially from isolated gastric varices usually is profuse, has a higher rate of recurrence than esophageal variceal bleeding , and is associated with decreased survival (cumulative mortality of fundal varices reaching as high as 52% at the end of 1 year). The optimal treatment for gastric variceal bleeding is still controversial, primarily because of the apparent ineffectiveness of conventional antivariceal therapy and the inclusion of patients with gastric varices located at different sites.
|
|
|
 |
|
|
Video Endoscopic Sequence 4 of 7.
Hemostasis was achieved using argon plasma coagulator APC.
Bleeding from gastric varices is often a serious medical emergency.
Although the incidence of bleeding from gastric varices is relatively low (10–36%), massive bleeding from gastric varices is life-threatening.
|
|
|
 |
|
|
Video Endoscopic Sequence 5 of 7.
The video clip displays the APC stopping the hemorrhage.
Endoscopic variceal ligation is safer and more efficacious than sclerotherapy as initial treatment of bleeding esophageal varices, whereas cyanoacrylate injection is the endoscopic treatment of choice for gastric varices. An adjuvant vasoactive agent is useful for the prevention of early rebleeding.
Follow-up endoscopic treatment is necessary in order to obliterate residual varices.
|
|
|
 |
|
|
Video Endoscopic Sequence 6 of 7.
Status post coagulation with APC.
|
|
|
 |
|
|
Video Endoscopic Sequence 7 of 7.
Status post APC application seen with magnifying endoscope.
Endoscopic ultrasonography is useful in the prediction of recurrence of varices and facilitates visualization and guidance of further treatment of gastric varices.
Medline.
|
|
|
 |
|
|
Video Endoscopic Sequence 1 of 5.
Large Gastric Varices.
This 56 year-old lady with esophagus-Gastric Varices.
|
|
|
 |
|
|
Video Endoscopic Sequence 2 of 5.
Development of gastric varices is an important manifestation of portal hypertension. In segmental portal hypertension, gastric varices originate from short gastric and gastroepiploic veins. In generalized portal hypertension, intrinsic veins at cardia participate in the formation of gastric varices. Endoscopy and/or splenoportovenography and a high index of suspicion are required for the diagnosis of gastric varices.
|
|
|
 |
|
|
Video Endoscopic Sequence 3 of 5.
Sarin’s classification of gastric varices
Figure 1
|
|
|
 |
|
|
Video Endoscopic Sequence 4 of 5.
Sarin et al. defined four subtypes of gastric varices (Figure 1). Gastro-oesophageal varices (GOVs) are associated with oesophageal varices along the lesser curve (type 1, GOV1), or along the fundus (type 2, GOV2). Isolated gastric varices (IGVs) are present in isolation in the fundus (IGV1) or at ectopic sites in the stomach or the first part of the duodenum (IGV2). Gastric varices may be primary (at initial presentation) or secondary (appearing after obliteration of oesophageal varices). GOV1, the commonest at 70% of gastric varices, are also known as cardial varices. GOV2 and IGV1, at 21% and 7% of gastric varices, respectively, together referred to as fundal varices. The incidence of bleeding is highest with IGV1 (78%), followed by GOV2 (55%), and much less for GOV1 and IGV2 at 10%. Although the mortality rate with GOV1 is high, endoscopic treatment of GOV1 is likely to be more successful than the other subtypes.
|
|
|
 |
|
|
Video Endoscopic Sequence 5 of 5.
The natural history of bleeding gastric varices differs from that of esophageal varices. Although the risk of bleeding from gastric varices is half that of oesophageal varices, the transfusion requirements and mortality once bleeding has occurred are greater particularly for IGV. It has been reported that patients with large gastric varices have a lower portal pressure than those with oesophageal varices, which may be as a result of the development of gastrorenal porto-systemic shunts, or large size of the varices resulting in increased variceal wall tension.
|
|
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
|
 |
|
|
Video Endoscopic Sequence 1 of 16.
Endoscopic Ablation with Cyanoacrylate Glue
This 49 year-old female was hospitalized in a social security hospital in El Salvador, She was discharged from the hospital on day 10, after that visit us for a therapeutical endoscopy.
An upper endoscopy was practiced shows gastric varices of the fundus with a small quantity of blood emerging from the varix.
|
|
|
 |
|
|
Video Endoscopic Sequence 2 of 16..
Although gastric varices tend to bleed less frequently than esophageal varices, the morbidity and mortality associated with gastric variceal hemorrhage are substantial.
Gastric varices are dilated submucosal veins in the stomach, which can be a life-threatening cause of upper gastrointestinal hemorrhage. They are most commonly found in patients with portal hypertension, or elevated pressure in the portal vein system, which may be a complication of cirrhosis. Gastric varices may also be found in patients with thrombosis of the splenic vein, into which the short gastric veins which drain the fundus of the stomach flow. The latter may be a complication of acute pancreatitis, pancreatic cancer, or other abdominal tumours.
|
|
|
 |
|
|
Video Endoscopic Sequence 3 of 16.
In the same day a therapeutic endoscopy a histoacryl injection is programed, under general anesthesia with endotracheal tube is achieved. Stigmata of recent bleeding is observed.
|
|
|
 |
|
|
Video Endoscopic Sequence 4 of 16.
More images and video clips.
|
|
|
 |
|
|
Video Endoscopic Sequence 5 of 16.
N-butyl-2-cyanoacrylate (Histoacryl) is a watery substance that polymerizes and hardens instantaneously when it comes into contact with blood. This unique property makes it attractive for use in obliterating varices. It is particularly useful in the treatment of fundic varices. Histoacryl is reconstituted with Lipiodol (0.8 mL in 0.5 mL), an oil-based radiopaque contrast agent). the therapeutic channel of the endoscope is first rinsed with 2mL of Lipiodol. The injection needle is then filled with 2mL of Lipiodol. The varix is punctured, and the Histoacryl-Lipiodol mixture is injected. Before retraction of the needle, residual glue is pushed into the varix with a further 2mL of Lipiodol. The needle is then retracted, and the catheter is rinsed with water. It is important at this juncture not to activate suction in the endoscope, and to continue irrigation to avoid contact between the glue and the lenses.
|
|
|
 |
|
|
Video Endoscopic Sequence 6 of 16..
The image and the video clip show the status of histoacryl injection.
When Histoacryl is mixed in a ratio of 0.5 cm3 (volume per tube of Histoacryl) to 0.8 cm' Lipiodol, hardening is delayed by approximately 20 seconds. The two components are drawn up together into a 2 ml syringe and then mixed by inverting the syringe several times. To help prevent Histoacryl from adhering to the catheter wall, several millilitres of Lipiodol are injected into the catheter.
|
|
|
 |
|
|
Video Endoscopic Sequence 7 of 16.
The image and the video clips show the second shot of histoacryl.
|
|
|
 |
|
|
Video Endoscopic Sequence 8 of 16.
The image and the video clips show the third shot of histoacryl.
|
|
|
 |
|
|
Video Endoscopic Sequence 9 of 16.
Hemostatic methods that use standard therapy for esophageal varices have not been found effective for gastric varices. Due to their large size and extensive distribution, it is difficult if not impossible to eradicate gastric varices with sclerotherapy or band ligation. More importantly, tissue necrosis resulting from these endoscopic interventions can cause significant and sometimes disastrous complications.
|
|
|
 |
|
|
Video Endoscopic Sequence 10 of 16.
Conceptually, cyanoacrylate glue provides an ideal endoscopic treatment for gastric varices. Native cyanoacrylate is a liquid with a consistency similar to water and therefore lends itself to intravariceal injection. When added to a physiologic medium such as blood, the cyanoacrylate rapidly polymerizes, forming a hard substance. Thus, after injection into a varix, the cyanoacrylate plugs the lumen. This results not only in rapid hemostasis in cases of active bleeding, but it also prevents the recurrence of bleeding from the treated varix.
|
|
|
 |
|
|
Video Endoscopic Sequence 11 of 16.
Histoacryl is highly effective for the treatment of bleeding gastric varices. The treatment failure-related mortality rate was almost a result of malignancy or underlying liver disease. Serious adverse event may appear although under experienced endoscopist.
|
|
|
 |
|
|
Video Endoscopic Sequence 12 of 16.
A follow up endoscopy one week later was performed.
Status post injection of histoacryl mixture.
|
|
|
 |
|
|
Video Endoscopic Sequence 13 of 16.
More images and video clips.
|
|
|
 |
|
|
Video Endoscopic Sequence 14 of 16.
Massive transfusions by nature lead to hemodilution, acidosis, hypothermia and ultimately coagulopathy. To minimize these complications it is recommended to replace plasma constituents and platelets with packed red blood cell infusions. A protocol with a replacement ratio of 5 PRBC, 5 FFP and 2 units of platelets minimizes bleeding, hemodilution and persistent thrombocytopenia.
|
|
|
 |
|
|
Video Endoscopic Sequence 15 of 16.
Status post variceal ligation is observed at the cardias.
|
|
|
 |
|
|
Video Endoscopic Sequence 16 of 16.
Fibrin and ulcers of post banding at the esophagus are displayed
|
|
|
 |
|
|
Video Endoscopic Sequence 1 of 4.
Large Gastric Varices.
This 72 year old female with a recurrent episode of bleeding from gastric varices. Seen on retroflexion are pendulous varices in the gastric cardia and fundus.
|
|
|
 |
|
|
Video Endoscopic Sequence 2 of 4.
Ulcerated Gastric Varix.
Primary gastric varices are said to be detected in 20% patients with portal hypertensions. The data suggests that gastric varices bleed less frequently (14%-16%) , but once it bleeds it is torrential and severe.
|
|
|
 |
|
|
Video Endoscopic Sequence 3 of 4.
The patient underwent Cyanoacrylate glue injection for her gastricvarices.
Variceal obstruction with cyanoacrylate tissue adhesive had been used successfully and most studies have achieved control of bleeding in almost 100% of patients.
|
|
|
 |
|
|
Video Endoscopic Sequence 4 of 4.
This image and the video clip was obtained with magnifying endoscope.
Gastric varices develop in patients with portal hypertension , including liver cirrhosis, idiopathic portal hypertension as well as left sided-local portal hypertension such as splenic vein thrombosis or splenic AV malformation. The inflow vein is the left gastric vein, posterior vein, or short gastric vein, while the outflow vein is the gastro-renal shunt in most of the patients with gastric varices. The form of the gastric varices is classified into three types of venous dilatation; tortuous type, notched type and tumor type according to the shape and size of the varices.
|
|
|
 |
|
|
Fundus Varices.
Fundus varices are observed in the maneuver of retroflexion, and the signs of recent bleeding are also observed.
Gastric varices usually accompany esophageal varices, although they may occur alone. They are located in the gastric fundus and are best appreciated endoscopically on retroflexed view.
|
|
|
 |
|
|
Enormous Erosioned Gastric Varix.
Gastric Varix of the fundus that caused severe gastrointestinal hemorrhage.
|
|
|
 |
|
|
Varices of the Gastric Fundus.
More commonly, bleeding gastric varices are associated with large esophageal varices and are due to underlying liver disease.
|
|
|
 |
|
|
Fundus Varices.
A 90 year-old female with fundus varices, recent bleeding activity is observed.
|
|
|
 |
|
|
Status Post Histoacryl.
Histoacryl was injected intravariceally.
Histoacryl injection sclerotherapy is highly effective for the treatment of bleeding gastric varices, with rare complications occurring both acutely and long-term. Therefore, Histoacryl injection sclerotherapy is considered to be the first choice of treatment for bleeding gastric varices, but the rate of recurrent bleeding is so high that further methods or devices still need to be developed in order to prevent gastric variceal rebleeding.
|
|
|
|